Diogo Pinto,  —

Long-term oxygen therapy may not benefit patients with mild to moderate chronic obstructive pulmonary disease (COPD) with low levels of oxygen in the blood (hypoxemia), a meta-analysis has shown. This type of therapy did not prolong life expectancy or decrease the risk of hospitalization in these patients, and did not…

AstraZeneca’s triple combination therapy PT010 (budesonide/glycopyrrolate/formoterol fumarate) improved lung function and reduced the rate of exacerbations in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) in a Phase 3 trial, compared with dual combination therapies. Results of the trial were published in the study, “Triple…

A 10-year study has identified several factors that are independent predictors of hospital mortality in critically ill patients with severe chronic obstructive pulmonary disease (COPD). These factors include a patient’s age, the need for mechanical ventilation, and disease severity, the study shows. The research, titled “Factors associated with hospital…

High frequency chest wall oscillation (HFCWO) vests, a type of airway clearance therapy used in several lung disorders, including chronic obstructive pulmonary disease (COPD), were not found to improve measures of lung function in healthy individuals in a recent study. The study, designed to assess the short-term…

Verona Pharma has started a Phase 2 clinical trial to evaluate the potential of its nebulized RPL554 as an add-on treatment to the approved Stiolto Respimat (tiotropium bromide/olodaterol) for the treatment of moderate to severe chronic obstructive pulmonary disease (COPD). A total of 75 patients are expected to…

Pulmatrix‘s branded generic of Spiriva HandiHaler, called PUR0200, was shown to promote similar improvements in lung function in patients with chronic obstructive pulmonary disease (COPD), but at significantly lower doses than Spiriva, according to a Phase 1 clinical trial. The study reporting the findings is titled “The pharmacokinetics,…

A 15-year study demonstrated how nontypeable Haemophilus influenzae (NTHi), one of the most important pathogens in chronic obstructive pulmonary disease (COPD), adapts and survives in patients’ airways over time. The research findings were reported in the journal Proceedings of the National Academy of Sciences, in a study titled “…

The long-term use of aspirin was found to reduce the severity of acute exacerbations in chronic obstructive pulmonary disease (AECOPD), including in-hospital mortality, invasive ventilation use, and hospital length-of-stay (LOS), researchers reported. The study, “The association of aspirin use with severity of acute exacerbation of chronic obstructive pulmonary disease:…