Author Archives: Marta Figueiredo PhD

Dark-Field Chest X-rays Could Improve Diagnosis, Early Detection

Dark-field chest X-ray imaging provides greater detail of lung microstructure than standard chest X-rays, and allows for the accurate diagnosis of chronic obstructive pulmonary disease (COPD), a study shows. “In the future dark-field X-rays could help improve early detection of COPD and other respiratory ailments,” Alexander Fingerle, MD, of the…

Antioxidant NAC Found to Ease Lung Scarring in Preclinical Study

Treatment with the antioxidant N-acetylcysteine (NAC) lowered blood levels of pro-inflammatory molecules and reduced lung scarring, or fibrosis, in a rat model of chronic obstructive pulmonary disease (COPD), a study shows. This beneficial effect was associated with the suppression of two molecules — von Willebrand factor (VWF) and p38 mitogen-activated…

Repeat Lung Injury Depletes Stem Cell Pool There, May Promote COPD

Repeated lung injury increases the biological age of lung stem cells and progressively diminishes their regenerative abilities, according to a study in mice and lab-grown human cells. These findings suggest that such repeat damage contributes to the abnormal repair and tissue remodeling that characterizes chronic obstructive pulmonary disease (COPD) and…

How Stem Cell Therapy Works to Ease COPD Described in Study

Treatment with human mesenchymal stem cells (MSCs) results in a strong, but temporary, reduction in pro-inflammatory molecules involved in chronic obstructive pulmonary disease (COPD), according to data from a Phase 1 clinical trial involving nine COPD patients. Notably, molecules directly produced by MSCs were identified as potential drivers of these…

Zephyr Valve Led to Sustained Benefits in Homogeneous Emphysema

The Zephyr Endobronchial Valve leads to sustained and significant improvements in lung function, exercise capacity, and quality of life in people with homogeneous emphysema, a severe form of chronic obstructive pulmonary disease (COPD), according to one-year data from the IMPACT clinical study. “This is very important data because…

COVID-19 Measures Linked to 53% Fewer COPD Hospitalizations

Hospitalizations for chronic obstructive pulmonary disease (COPD) dropped by half after the implementation of public health measures to curb the spread of COVID-19 infections, according to a U.S. study. This reduction in COPD hospital admissions was 36% greater than “the declines seen in other serious medical conditions, including…

Mesenchymal Stem Cells Show Potential to Treat NTM Lung Infections

Treatment with human mesenchymal stem cells (MSCs) effectively lessened hard-to-treat non-tuberculous mycobacteria (NTM) lung infection, and its associated weight loss, in a new mouse model susceptible to these infections, an early study reported. “The potential to use human mesenchymal stem cells to treat difficult lung infections is promising,” Anthony Atala,…

FDA OKs Pivotal Trial Testing RheOx System in Chronic Bronchitis

The U.S. Food and Drug Administration (FDA) has cleared the start of an international pivotal trial to test the RheOx System, Gala Therapeutics’ medical device, in adults with chronic obstructive pulmonary disease (COPD) who have moderate to severe chronic bronchitis. “Chronic bronchitis is a debilitating disease which results…

Noninvasive Home Ventilation Linked to Lower Risk of Death, ER Visits

Noninvasive ventilation at home, known as NIVH, is associated with a significantly lower risk of death, hospitalization, and emergency room (ER) visits among chronic obstructive pulmonary disease (COPD) patients with chronic respiratory failure, according to a study based on Medicare data. Notably, the NIVH-associated reduced risk of hospitalization was…