Therapeutic Solutions International (TSOI) reported discovering a new mechanism of action for JadiCell, its investigative stem cell therapy for chronic obstructive pulmonary disease (COPD) and other conditions. Working in animal models, scientists found that JadiCell’s protective effects were dependent on certain immune B-cells and a signaling molecule…

Note: This story was updated June 6, 2022, to note that the U.S. Food and Drug Administration has assigned an Investigational New Drug application (IND) number to Therapeutic Solutions International experimental JadiCell therapy. The FDA has not yet approved the company’s IND application. The U.S. Food and Drug Administration’s review…

Treatment with immune-suppressing myeloid-derived suppressor cells alongside JadiCell — an investigational stem cell therapy from Therapeutic Solutions International (TSOI) for chronic obstructive pulmonary disease (COPD) — led to more significant reductions in lung damage in mice compared with either treatment alone. Using them together also enhanced pulmonary regeneration…

Therapeutic Solutions International (TSOI) is seeking permission from the U.S. Food and Drug Administration (FDA) to conduct a Phase 1 study of JadiCell, its investigational stem cell therapy, in 10 people with advanced chronic obstructive pulmonary disease (COPD). The request — submitted in the form of an investigational…

JadiCells, the investigational stem cell therapy by Therapeutic Solutions International (TSOI), preserved lung function and increased the number of cells thought to have a role in lung repair in mice with inflammation-induced lung injury, the company announced. These preclinical findings further support the potential of JadiCells to both prevent…

Therapeutic Solutions International has filed a patent covering the therapeutic use of JadiCells — a type of mesenchymal stem cell derived from cells lining the umbilical cord — and its various combinations in treating chronic obstructive pulmonary disease (COPD). The patent application is supported by new data indicating…