News

New Atlas of COPD Lung Cells May Help Advance Treatments

A team of researchers have created a comprehensive blueprint of cells that are in the lungs of chronic obstructive pulmonary disease (COPD) patients, which helped them identify previously unknown cell subpopulations and changes in gene activity and cellular interactions. “Our analysis identified novel changes in gene expression [activity] and…

Promising Compound Derived From Tick Saliva May Help Stop Flare-ups

Animal and human studies highlight the potential of nomacopan, an investigational inhaled medicine to alleviate severe exacerbations caused by inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD). Akari Therapeutics, the company developing the therapy, is collaborating with Inhalation Sciences to refine the dosing and pharmacological…

Verona Completes Enrollment for ENHANCE-2 Trial of Ensifentrine

Verona Pharma has completed patient enrollment for ENHANCE-2, a Phase 3 clinical trial evaluating the safety and efficacy of ensifentrine, an inhalation therapy for chronic obstructive pulmonary disease (COPD). According to Verona, the trial exceeded its enrollment target of 800 participants, even amid the COVID-19 pandemic. Top-line data are…

Questionnaires May Help Diagnose COPD When Resources Are Scarce

Standardized questionnaires can effectively be used to help diagnose chronic obstructive pulmonary disease (COPD) in settings where healthcare resources may be limited, according to a new study. The study, “Discriminative Accuracy of Chronic Obstructive Pulmonary Disease Screening Instruments in 3 Low- and Middle-Income Country Settings,” was…

First COPD Patient Enrolled in Phase 4 Study of Yupelri vs. Spiriva

A first patient has been enrolled in a Phase 4 study of the effectiveness of Yupelri (revefenacin) against Spiriva (tiotropium) in improving lung health in adults with severe chronic obstructive pulmonary disease (COPD). The respective safety of these two approved, once-daily COPD maintenance treatments will also be evaluated. Yupelri, developed…

Chinese Remedy XBCQ Improved Lung Function in COPD Mice

A Chinese remedy called Xuanbai Chengqi decoction, or XBCQ, used to treat chronic obstructive pulmonary disease (COPD), modulated immune cells, improved lung function, and reduced lung inflammation by potentially changing the gut microbiome of mice with the disease, a study suggested. “XBCQ could alleviate COPD exacerbations by reshaping the gut…

‘Rome Proposal’ Sets Framework for Classifying COPD Exacerbations

An international team of researchers has published a new framework, dubbed the Rome proposal, for defining and classifying exacerbations of chronic obstructive pulmonary disease (COPD). “The ‘Rome Proposal’ represents an important milestone for better understanding and treating a very important and troubling component of COPD progression and, the prospect…